Place the chicken tenders in a bowl. If using boneless, skinless chicken breasts, cut them into long strips. Add cayenne pepper, garlic powder, onion powder, Cajun spice, oregano, salt, pepper, and buttermilk. Mix well and marinate in the refrigerator for 4 hours.
Combine all-purpose flour, paprika, cayenne pepper, garlic powder, and salt in a large bowl, and stir to combine well. Set aside.
After 4 hours, remove the chicken strips from the marinade and coat them evenly with the flour mixture in the bowl. Place the coated chicken strips on a plate and let them sit at room temperature for 20 minutes to absorb.
After resting, dip the chicken strips in the flour mixture once more before frying. Heat cooking oil in a frying pan to 350°F – 375°F (176°C – 190°C). Deep fry the chicken for 2 minutes on each side, or until golden brown.
Transfer the fried chicken to a plate lined with paper towels to absorb excess oil. Drizzle the spiced oil over the chicken and serve immediately.
After frying the chicken tenders, let the frying oil cool for 10 minutes. Combine 1 tablespoon of the oil with cayenne pepper and paprika in a small dish and whisk until well mixed.